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Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer
The Journal of Pathology ( IF 7.3 ) Pub Date : 2024-01-17 , DOI: 10.1002/path.6238 Chowdhury Arif Jahangir 1 , David B Page 2 , Glenn Broeckx 3, 4 , Claudia A Gonzalez 1 , Caoimbhe Burke 1 , Clodagh Murphy 1 , Jorge S Reis‐Filho 5 , Amy Ly 6 , Paul W Harms 7 , Rajarsi R Gupta 8 , Michael Vieth 9 , Akira I Hida 10 , Mohamed Kahila 11 , Zuzana Kos 12 , Paul J van Diest 13, 14 , Sara Verbandt 15 , Jeppe Thagaard 16, 17 , Reena Khiroya 18 , Khalid Abduljabbar 19 , Gabriela Acosta Haab 20 , Balazs Acs 21, 22 , Sylvia Adams 23, 24 , Jonas S Almeida 25 , Isabel Alvarado‐Cabrero 26 , Farid Azmoudeh‐Ardalan 27 , Sunil Badve 28 , Nurkhairul Bariyah Baharun 29 , Enrique R Bellolio 30 , Vydehi Bheemaraju 31 , Kim RM Blenman 32, 33 , Luciana Botinelly Mendonça Fujimoto 34 , Octavio Burgues 35 , Alexandros Chardas 36 , Maggie Chon U Cheang 37 , Francesco Ciompi 38 , Lee AD Cooper 39 , An Coosemans 40 , Germán Corredor 41 , Flavio Luis Dantas Portela 42 , Frederik Deman 3 , Sandra Demaria 43, 44 , Sarah N Dudgeon 45 , Mahmoud Elghazawy 46, 47 , Claudio Fernandez‐Martín 48 , Susan Fineberg 49 , Stephen B Fox 50 , Jennifer M Giltnane 51 , Sacha Gnjatic 52 , Paula I Gonzalez‐Ericsson 53 , Anita Grigoriadis 54, 55 , Niels Halama 56 , Matthew G Hanna 57 , Aparna Harbhajanka 58 , Steven N Hart 59 , Johan Hartman 22, 60 , Stephen Hewitt 61 , Hugo M Horlings 62 , Zaheed Husain 63 , Sheeba Irshad 64 , Emiel AM Janssen 65, 66 , Tatsuki R Kataoka 67 , Kosuke Kawaguchi 68 , Andrey I Khramtsov 69 , Umay Kiraz 65, 66 , Pawan Kirtani 70 , Liudmila L Kodach 71 , Konstanty Korski 72 , Guray Akturk 73 , Ely Scott 74 , Anikó Kovács 75, 76 , Anne‐Vibeke Lænkholm 77, 78 , Corinna Lang‐Schwarz 9 , Denis Larsimont 79 , Jochen K Lennerz 80 , Marvin Lerousseau 81, 82, 83 , Xiaoxian Li 84 , Anant Madabhushi 85 , Sai K Maley 86 , Vidya Manur Narasimhamurthy 87 , Douglas K Marks 23 , Elizabeth S McDonald 88 , Ravi Mehrotra 89, 90 , Stefan Michiels 91 , Durga Kharidehal 92 , Fayyaz ul Amir Afsar Minhas 93 , Shachi Mittal 94 , David A Moore 95 , Shamim Mushtaq 96 , Hussain Nighat 97 , Thomas Papathomas 98, 99 , Frederique Penault‐Llorca 100 , Rashindrie D Perera 101, 102 , Christopher J Pinard 103, 104, 105, 106 , Juan Carlos Pinto‐Cardenas 107 , Giancarlo Pruneri 108, 109 , Lajos Pusztai 110, 111 , Nasir Mahmood Rajpoot 112 , Bernardo Leon Rapoport 113, 114 , Tilman T Rau 115 , Joana M Ribeiro 116 , David Rimm 117, 118 , Anne Vincent‐Salomon 119 , Joel Saltz 120 , Shahin Sayed 121 , Evangelos Hytopoulos 121, 122 , Sarah Mahon 123 , Kalliopi P Siziopikou 124 , Christos Sotiriou 125, 126 , Albrecht Stenzinger 127 , Maher A Sughayer 128 , Daniel Sur 129 , Fraser Symmans 130 , Sunao Tanaka 131 , Timothy Taxter 132 , Sabine Tejpar 15 , Jonas Teuwen 133 , E Aubrey Thompson 134 , Trine Tramm 135 , William T Tran 136 , Jeroen van der Laak 37 , Gregory E Verghese 54, 55 , Giuseppe Viale 137 , Noorul Wahab 138 , Thomas Walter 81, 82, 83 , Yannick Waumans 139 , Hannah Y Wen 57 , Wentao Yang 140 , Yinyin Yuan 141 , John Bartlett 142 , Sibylle Loibl 143 , Carsten Denkert 144 , Peter Savas 145, 146 , Sherene Loi 145, 147 , Elisabeth Specht Stovgaard 148 , Roberto Salgado 3, 145 , William M Gallagher 1 , Arman Rahman 149
The Journal of Pathology ( IF 7.3 ) Pub Date : 2024-01-17 , DOI: 10.1002/path.6238 Chowdhury Arif Jahangir 1 , David B Page 2 , Glenn Broeckx 3, 4 , Claudia A Gonzalez 1 , Caoimbhe Burke 1 , Clodagh Murphy 1 , Jorge S Reis‐Filho 5 , Amy Ly 6 , Paul W Harms 7 , Rajarsi R Gupta 8 , Michael Vieth 9 , Akira I Hida 10 , Mohamed Kahila 11 , Zuzana Kos 12 , Paul J van Diest 13, 14 , Sara Verbandt 15 , Jeppe Thagaard 16, 17 , Reena Khiroya 18 , Khalid Abduljabbar 19 , Gabriela Acosta Haab 20 , Balazs Acs 21, 22 , Sylvia Adams 23, 24 , Jonas S Almeida 25 , Isabel Alvarado‐Cabrero 26 , Farid Azmoudeh‐Ardalan 27 , Sunil Badve 28 , Nurkhairul Bariyah Baharun 29 , Enrique R Bellolio 30 , Vydehi Bheemaraju 31 , Kim RM Blenman 32, 33 , Luciana Botinelly Mendonça Fujimoto 34 , Octavio Burgues 35 , Alexandros Chardas 36 , Maggie Chon U Cheang 37 , Francesco Ciompi 38 , Lee AD Cooper 39 , An Coosemans 40 , Germán Corredor 41 , Flavio Luis Dantas Portela 42 , Frederik Deman 3 , Sandra Demaria 43, 44 , Sarah N Dudgeon 45 , Mahmoud Elghazawy 46, 47 , Claudio Fernandez‐Martín 48 , Susan Fineberg 49 , Stephen B Fox 50 , Jennifer M Giltnane 51 , Sacha Gnjatic 52 , Paula I Gonzalez‐Ericsson 53 , Anita Grigoriadis 54, 55 , Niels Halama 56 , Matthew G Hanna 57 , Aparna Harbhajanka 58 , Steven N Hart 59 , Johan Hartman 22, 60 , Stephen Hewitt 61 , Hugo M Horlings 62 , Zaheed Husain 63 , Sheeba Irshad 64 , Emiel AM Janssen 65, 66 , Tatsuki R Kataoka 67 , Kosuke Kawaguchi 68 , Andrey I Khramtsov 69 , Umay Kiraz 65, 66 , Pawan Kirtani 70 , Liudmila L Kodach 71 , Konstanty Korski 72 , Guray Akturk 73 , Ely Scott 74 , Anikó Kovács 75, 76 , Anne‐Vibeke Lænkholm 77, 78 , Corinna Lang‐Schwarz 9 , Denis Larsimont 79 , Jochen K Lennerz 80 , Marvin Lerousseau 81, 82, 83 , Xiaoxian Li 84 , Anant Madabhushi 85 , Sai K Maley 86 , Vidya Manur Narasimhamurthy 87 , Douglas K Marks 23 , Elizabeth S McDonald 88 , Ravi Mehrotra 89, 90 , Stefan Michiels 91 , Durga Kharidehal 92 , Fayyaz ul Amir Afsar Minhas 93 , Shachi Mittal 94 , David A Moore 95 , Shamim Mushtaq 96 , Hussain Nighat 97 , Thomas Papathomas 98, 99 , Frederique Penault‐Llorca 100 , Rashindrie D Perera 101, 102 , Christopher J Pinard 103, 104, 105, 106 , Juan Carlos Pinto‐Cardenas 107 , Giancarlo Pruneri 108, 109 , Lajos Pusztai 110, 111 , Nasir Mahmood Rajpoot 112 , Bernardo Leon Rapoport 113, 114 , Tilman T Rau 115 , Joana M Ribeiro 116 , David Rimm 117, 118 , Anne Vincent‐Salomon 119 , Joel Saltz 120 , Shahin Sayed 121 , Evangelos Hytopoulos 121, 122 , Sarah Mahon 123 , Kalliopi P Siziopikou 124 , Christos Sotiriou 125, 126 , Albrecht Stenzinger 127 , Maher A Sughayer 128 , Daniel Sur 129 , Fraser Symmans 130 , Sunao Tanaka 131 , Timothy Taxter 132 , Sabine Tejpar 15 , Jonas Teuwen 133 , E Aubrey Thompson 134 , Trine Tramm 135 , William T Tran 136 , Jeroen van der Laak 37 , Gregory E Verghese 54, 55 , Giuseppe Viale 137 , Noorul Wahab 138 , Thomas Walter 81, 82, 83 , Yannick Waumans 139 , Hannah Y Wen 57 , Wentao Yang 140 , Yinyin Yuan 141 , John Bartlett 142 , Sibylle Loibl 143 , Carsten Denkert 144 , Peter Savas 145, 146 , Sherene Loi 145, 147 , Elisabeth Specht Stovgaard 148 , Roberto Salgado 3, 145 , William M Gallagher 1 , Arman Rahman 149
Affiliation
Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour samples has great potential to guide appropriate treatment choices. Moreover, the emergence of novel multi-marker imaging approaches can now provide unprecedented insights into the tumour microenvironment, including the potential interplay between various cell types. However, there are significant challenges to widespread integration of these technologies in daily research and clinical practice. This review addresses the challenges and potential solutions within a structured framework of action from a regulatory and clinical trial perspective. New developments within the field of immunophenotyping using multiplexed tissue imaging platforms and associated digital pathology are also described, with a specific focus on translational implications across different subtypes of cancer. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
中文翻译：
基于图像的癌症组织多重免疫分析：转化意义。国际乳腺癌免疫肿瘤学生物标志物工作组的报告
免疫肿瘤学领域的最新进展给癌症患者的治疗带来了革命性的变化。已发现肿瘤的免疫特征对于预测各种癌症的疾病预后和治疗反应具有关键价值。多重免疫组织化学和免疫荧光已成为同时检测单个组织切片中多种蛋白质生物标志物的有效工具，从而在保存组织样本的同时扩大了分子和免疫分析的机会。通过确定分布在混合细胞群中的单个肿瘤细胞的表型，通过肿瘤样本的高通量多重免疫表型分析来鉴定临床相关生物标志物，具有指导适当治疗选择的巨大潜力。此外，新型多标记成像方法的出现现在可以为肿瘤微环境提供前所未有的见解，包括各种细胞类型之间的潜在相互作用。然而，将这些技术广泛整合到日常研究和临床实践中面临着重大挑战。本综述从监管和临床试验的角度解决了结构化行动框架内的挑战和潜在解决方案。还描述了使用多重组织成像平台和相关数字病理学进行免疫表型分析领域的新进展，特别关注不同癌症亚型的转化影响。© 2024 作者。《病理学杂志》由 John Wiley & Sons Ltd 代表大不列颠及爱尔兰病理学会出版。
更新日期：2024-01-17
中文翻译：
基于图像的癌症组织多重免疫分析：转化意义。国际乳腺癌免疫肿瘤学生物标志物工作组的报告
免疫肿瘤学领域的最新进展给癌症患者的治疗带来了革命性的变化。已发现肿瘤的免疫特征对于预测各种癌症的疾病预后和治疗反应具有关键价值。多重免疫组织化学和免疫荧光已成为同时检测单个组织切片中多种蛋白质生物标志物的有效工具，从而在保存组织样本的同时扩大了分子和免疫分析的机会。通过确定分布在混合细胞群中的单个肿瘤细胞的表型，通过肿瘤样本的高通量多重免疫表型分析来鉴定临床相关生物标志物，具有指导适当治疗选择的巨大潜力。此外，新型多标记成像方法的出现现在可以为肿瘤微环境提供前所未有的见解，包括各种细胞类型之间的潜在相互作用。然而，将这些技术广泛整合到日常研究和临床实践中面临着重大挑战。本综述从监管和临床试验的角度解决了结构化行动框架内的挑战和潜在解决方案。还描述了使用多重组织成像平台和相关数字病理学进行免疫表型分析领域的新进展，特别关注不同癌症亚型的转化影响。© 2024 作者。《病理学杂志》由 John Wiley & Sons Ltd 代表大不列颠及爱尔兰病理学会出版。
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