Abstarct 5β-Cardenolides are pharmaceutically important metabolites of the specialized metabolism of Digitalis lanata. They were used over decades to treat cardiac insufficiency and supraventricular tachycardia. Since the 1960s, plant scientists have known that progesterone is an essential precursor of cardenolide formation. Therefore, plant progesterone biosynthesis was mainly analyzed in species of the cardenolide-containing genus Digitalis during the following decades. Today, Digitalis enzymes catalyzing the main steps of progesterone biosynthesis are known. Most of them were found in a broad range of organisms. This review will summarize the findings of 60 years of research on plant progesterone metabolism with a particular focus on the recent results in Digitalis lanata and other plants.

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洋地黄和其他植物中的黄体酮代谢 - 60 年研究和最新结果

Abstarct 5β-Cardenolides 是毛地黄专门代谢的药学上重要的代谢物。几十年来，它们一直用于治疗心功能不全和室上性心动过速。自 20 世纪 60 年代以来，植物科学家已经知道黄体酮是强心苷酸形成的重要前体。因此，在接下来的几十年里，植物黄体酮生物合成主要在含卡烯内酯的洋地黄属物种中进行分析。如今，已知毛地黄酶催化孕酮生物合成的主要步骤。其中大多数存在于多种生物体中。这篇综述将总结 60 年来植物孕酮代谢的研究成果，特别关注毛地黄和其他植物的最新研究结果。