Microgravity in space impacts human health. In particular, thyroid cancer, which has a high incidence rate, has been the subject of numerous studies with respect to microgravity. However, most studies have focused on Western follicular thyroid cancer cell lines, while data regarding the effects of microgravity on Asian cell lines are lacking. Therefore, we aimed to investigate the effect of simulated ground-based microgravity on two Korean thyroid cancer cell lines, namely SNU-790 and SNU-80. We found that both cell lines formed multicellular spheroids under simulated microgravity. Gene expression analysis revealed that in SNU-790 cells, histone-related genes were upregulated and microRNA-related genes were downregulated. Meanwhile, in SNU-80 cells, genes related to the cellular response to hypoxia were downregulated. These findings contribute to a better understanding of the effects of microgravity on thyroid cancer cells. Further validation studies and clinical significance analyses are needed to fully understand the implications of these findings.

太空中的微重力影响人类健康。特别是甲状腺癌，其发病率很高，已成为许多微重力研究的主题。然而，大多数研究都集中在西方滤泡性甲状腺癌细胞系上，而缺乏有关微重力对亚洲细胞系影响的数据。因此，我们的目的是研究模拟地面微重力对两种韩国甲状腺癌细胞系（即 SNU-790 和 SNU-80）的影响。我们发现两种细胞系在模拟微重力下形成多细胞球体。基因表达分析显示，在SNU-790细胞中，组蛋白相关基因上调，而microRNA相关基因下调。与此同时，在 SNU-80 细胞中，与细胞缺氧反应相关的基因被下调。这些发现有助于更好地了解微重力对甲状腺癌细胞的影响。需要进一步的验证研究和临床意义分析来充分理解这些发现的含义。