present barriers for more widespread adoption by a larger proportion of individuals with kidney failure. These limitations include device weight and bulk, ergonomics considerations, technical complexity, vascular access challenges, and limited remote patient monitoring. Recent years have witnessed a resurgence in research and development of prototype wearable kidney replacement devices incorporating innovations in miniaturization, new biomaterials, and new methods for toxin clearance and dialysate regeneration. Recent work has built on five decades of incremental innovation in wearable dialysis concepts and prototypes, starting from the work of Kolff in the 1970s. Wearable dialysis devices that successfully overcome key persistent barriers to successful development and adoption of these technologies will radically reshape the landscape of kidney replacement therapies and have the potential to dramatically improve the lives of individuals living with kidney failure. Although the past two decades have seen substantial proportional growth of home hemodialysis (HD) in the United States, the absolute number of patients treated with home HD remains small. Currently available stationary hemodialysis devices for use in the home have inherent limitations that are represent barriers for more widespread adoption by a larger proportion of individuals with kidney failure. These limitations include device weight and bulk, ergonomics considerations, technical complexity, vascular access challenges, and limited remote patient monitoring. Recent years have witnessed a resurgence in research and development of prototype wearable kidney replacement devices incorporating innovations in miniaturization, new biomaterials, and new methods for toxin clearance and dialysate regeneration. Recent work has built on five decades of incremental innovation in wearable dialysis concepts and prototypes, starting from the work of Kolff in the 1970s. Wearable dialysis devices that successfully overcome key persistent barriers to successful development and adoption of these technologies will radically reshape the landscape of kidney replacement therapies and have the potential to dramatically improve the lives of individuals living with kidney failure. Copyright © 2024 by the American Society of Nephrology...

中文翻译：

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从家庭到可穿戴血液透析：障碍、进步和机遇

为更大比例的肾功能衰竭患者更广泛地采用存在障碍。这些限制包括设备重量和体积、人体工程学考虑、技术复杂性、血管通路挑战以及有限的远程患者监测。近年来，原型可穿戴肾脏替代设备的研究和开发重新兴起，该设备融合了小型化、新生物材料以及毒素清除和透析液再生新方法的创新。最近的工作建立在可穿戴式透析概念和原型方面五年来渐进式创新的基础上，从 20 世纪 70 年代 Kolff 的工作开始。可穿戴式透析设备成功克服了成功开发和采用这些技术的关键持续障碍，将从根本上重塑肾脏替代疗法的格局，并有可能显着改善肾衰竭患者的生活。尽管过去二十年美国家庭血液透析（HD）的比例大幅增长，但接受家庭血液透析治疗的患者绝对数量仍然很少。目前用于家庭使用的固定式血液透析设备具有固有的局限性，这阻碍了更多肾衰竭患者更广泛地采用。这些限制包括设备重量和体积、人体工程学考虑、技术复杂性、血管通路挑战以及有限的远程患者监测。近年来，原型可穿戴肾脏替代设备的研究和开发重新兴起，该设备融合了小型化、新生物材料以及毒素清除和透析液再生新方法的创新。最近的工作建立在可穿戴式透析概念和原型方面五年来渐进式创新的基础上，从 20 世纪 70 年代 Kolff 的工作开始。可穿戴式透析设备成功克服了成功开发和采用这些技术的关键持续障碍，将从根本上重塑肾脏替代疗法的格局，并有可能显着改善肾衰竭患者的生活。版权所有 © 2024 美国肾脏病学会...