RNA modifications have emerged as important mechanisms of gene regulation. Developmental, metabolic, and cell cycle regulatory processes are all affected by epitranscriptomic modifications, which control gene expression in a dynamic manner. The hepatic tissue is highly metabolically active and has an impressive ability to regenerate after injury. Cell proliferation, differentiation, and metabolism, which are all essential to the liver response to injury and regeneration, are regulated via RNA modification. Two such modifications, -methyladenosine (mA)and 5-methylcytosine (mC), have been identified as prognostic disease markers and potential therapeutic targets for liver diseases. Here, we describe progress in understanding the role of RNA modifications in liver biology and disease and discuss specific areas where unexpected results could lead to improved future understanding.

中文翻译：

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表观转录组修饰对肝病的影响

RNA修饰已成为基因调控的重要机制。发育、代谢和细胞周期调控过程都受到表观转录组修饰的影响，表观转录组修饰以动态方式控制基因表达。肝组织代谢活跃，损伤后具有令人印象深刻的再生能力。细胞增殖、分化和代谢对于肝脏对损伤和再生的反应至关重要，并通过 RNA 修饰进行调节。两种此类修饰，β-甲基腺苷 (mA) 和 5-甲基胞嘧啶 (mC)，已被确定为预后疾病标记物和肝病的潜在治疗靶点。在这里，我们描述了理解 RNA 修饰在肝脏生物学和疾病中的作用的进展，并讨论了意想不到的结果可能导致未来加深理解的特定领域。