In this study, the solubility of the tramadol hydrochloride (T-HCl) drug in supercritical carbon dioxide (SC-CO₂) was determined for the first time. The experiments were conducted at various operating pressures (100–270 bar) and temperatures (308–338 K). The solubility of T-HCl ranged from 0.309 × 10⁻⁴ to 1.384 × 10⁻⁴ in terms of mole fraction. Two different models, namely the Soave-Redlich-Kwong (SRK) and the simplified perturbed chain statistical associating fluid theory (sPC-SAFT) EoSs, along with seven semi-empirical correlations (including the Kumar-Johnston, Sung-Shim, Garlapati and Madras, Chrastil, Bian et al., Bartle et al., and Sodeifian et al., models), were employed to predict the solubility of T-HCl in SC-CO₂. The findings indicated that the sPC-SAFT EoS (with an average absolute relative deviation of 10.18%) and the Sung-Shim correlation (with an average absolute relative deviation of 7.29%) outperformed the other models, respectively. The total, solvation, and vaporization enthalpies of the T-HCl/SC-CO₂ binary system were estimated by applying these semi-empirical correlations.

本研究首次测定了盐酸曲马多（T-HCl）药物在超临界二氧化碳（SC-CO _{2 ）中}的溶解度。实验在不同的操作压力（100–270 bar）和温度（308–338 K）下进行。T-HCl的溶解度以摩尔分数计为0.309×10 ^-4至1.384×10 ^{-4 。}两种不同的模型，即 Soave-Redlich-Kwong (SRK) 和简化扰动链统计关联流体理论 (sPC-SAFT) EoS，以及七个半经验相关性（包括 Kumar-Johnston、Sung-Shim、Garlapati 和Madras、Chrastil、Bian 等人、Bartle 等人和 Sodeifian 等人（模型）被用来预测 T-HCl 在 SC-CO ₂中的溶解度。研究结果表明，sPC-SAFT EoS（平均绝对相对偏差为 10.18%）和 Sung-Shim 相关性（平均绝对相对偏差为 7.29%）分别优于其他模型。通过应用这些半经验相关性来估计T-HCl/SC-CO _{2二元系统}的总、溶剂化和汽化焓。