Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches,Nanoscale Horizons

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Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches
Nanoscale Horizons ( IF 8.0 ) Pub Date : 2024-01-08 , DOI: 10.1039/d3nh00578j
Anshuo Li _{1,

2} , Jiawei Yang ₁ , Yuchu He ₂ , Jin Wen ₁ , Xinquan Jiang ₁

Affiliation

Precision drug delivery and multimodal synergistic therapy are crucial in treating diverse ailments, such as cancer, tissue damage, and degenerative diseases. Electrodes that emit electric pulses have proven effective in enhancing molecule release and permeability in drug delivery systems. Moreover, the physiological electrical microenvironment plays a vital role in regulating biological functions and triggering action potentials in neural and muscular tissues. Due to their unique noncentrosymmetric structures, many 2D materials exhibit outstanding piezoelectric performance, generating positive and negative charges under mechanical forces. This ability facilitates precise drug targeting and ensures high stimulus responsiveness, thereby controlling cellular destinies. Additionally, the abundant active sites within piezoelectric 2D materials facilitate efficient catalysis through piezochemical coupling, offering multimodal synergistic therapeutic strategies. However, the full potential of piezoelectric 2D nanomaterials in drug delivery system design remains underexplored due to research gaps. In this context, the current applications of piezoelectric 2D materials in disease management are summarized in this review, and the development of drug delivery systems influenced by these materials is forecast.

中文翻译：

推进压电二维纳米材料在药物输送系统和治疗方法中的应用

精准药物输送和多模式协同治疗对于治疗癌症、组织损伤和退行性疾病等多种疾病至关重要。发射电脉冲的电极已被证明可以有效增强药物输送系统中的分子释放和渗透性。此外，生理电微环境在调节生物功能和触发神经和肌肉组织的动作电位方面起着至关重要的作用。由于其独特的非中心对称结构，许多二维材料表现出出色的压电性能，在机械力作用下产生正电荷和负电荷。这种能力有助于精确的药物靶向并确保高刺激反应性，从而控制细胞的命运。此外，压电二维材料中丰富的活性位点通过压电化学耦合促进有效催化，提供多模式协同治疗策略。然而，由于研究空白，压电二维纳米材料在药物输送系统设计中的全部潜力仍未得到充分开发。在此背景下，本文总结了目前压电二维材料在疾病管理中的应用，并对受这些材料影响的药物输送系统的发展进行了展望。

更新日期：2024-01-08

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