Hyperlactatemia and anemia commonly coexist and their crosstalk is a longstanding mystery with elusive mechanisms involved in physical activities, infections, cancers, and genetic disorders. For instance, hyperlactatemia leads to iron restriction by upregulating hepatic hepcidin expression. Increasing evidence also points to lactate as a crucial signaling molecule rather than merely a metabolic byproduct. Here, we discuss the mutual influence between anemia and hyperlactatemia. This opinion calls for a reconsideration of the multifaceted roles of lactate and lactylation in anemia and emphasizes the need to fill knowledge gaps, including the dose dependence of lactate’s effects, its sources, and its subcellular localization.

中文翻译：

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探讨高乳酸血症与贫血之间的关系

高乳酸血症和贫血通常共存，它们的串扰是一个长期存在的谜团，其机制难以捉摸，涉及体力活动、感染、癌症和遗传性疾病。例如，高乳酸血症通过上调肝脏铁调素表达导致铁限制。越来越多的证据还表明，乳酸是一种重要的信号分子，而不仅仅是一种代谢副产物。在这里，我们讨论贫血和高乳酸血症之间的相互影响。该观点呼吁重新考虑乳酸和乳酸化在贫血中的多方面作用，并强调需要填补知识空白，包括乳酸作用的剂量依赖性、其来源及其亚细胞定位。