Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatories. Multiple clinical trials have commenced to evaluate the efficacy of such agents against age-associated diseases including diabetes, cardiovascular disease, cancer, and neurodegenerative diseases. There are reasonable expectations that drugs able to decelerate or reverse aging processes will also exert broad disease-preventing or -attenuating effects. Hence, the outcome of past, ongoing, and future disease-specific trials may pave the way to the development of new anti-aging medicines. Drugs approved for specific disease indications may subsequently be repurposed for the treatment of organism-wide aging consequences.

中文翻译：

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探索抗衰老药物的人体试验


在此，我们总结了目前已在临床测试的八种有前途的药物和天然化合物的知识：二甲双胍、NAD 前体、胰高血糖素样肽-1 受体激动剂、TORC1 抑制剂、亚精胺、senolytics、益生菌和抗炎药。多项临床试验已开始评估此类药物对抗年龄相关疾病的功效，包括糖尿病、心血管疾病、癌症和神经退行性疾病。人们合理地预期，能够减缓或逆转衰老过程的药物也将发挥广泛的疾病预防或减轻作用。因此，过去、正在进行和未来的特定疾病试验的结果可能为开发新的抗衰老药物铺平道路。批准用于特定疾病适应症的药物随后可能会被重新用于治疗整个机体的衰老后果。