Throughout an individual’s life, somatic cells acquire cancer-associated mutations. A fraction of these mutations trigger tumour formation, a phenomenon partly driven by the interplay of mutant and wild-type cell clones competing for dominance; conversely, other mutations function against tumour initiation. This mechanism of ‘cell competition’, can shift clone dynamics by evaluating the relative status of clonal populations, promoting ‘winners’ and eliminating ‘losers’. This review examines the role of cell competition in the context of tumorigenesis, tumour progression and therapeutic intervention.

中文翻译：

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从果蝇到哺乳动物的细胞竞争和癌症

在个体的一生中，体细胞会获得与癌症相关的突变。这些突变中的一部分会引发肿瘤形成，这种现象部分是由突变型细胞克隆和野生型细胞克隆争夺主导地位的相互作用驱动的。相反，其他突变会抑制肿瘤的发生。这种“细胞竞争”机制可以通过评估克隆群体的相对状态、提升“赢家”并消除“输家”来改变克隆动态。本综述探讨了细胞竞争在肿瘤发生、肿瘤进展和治疗干预中的作用。