Cytoplasmic mislocalization of TDP-43 in neurodegenerative disease affects mRNA maturation and protein levels of stathmin-2, leading to a reduction in axon diameter and tearing of outer myelin layers and thereby disrupting neuronal function.

中文翻译：

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协调轴突组织


神经退行性疾病中 TDP-43 的细胞质错误定位会影响 stathmin-2 的 mRNA 成熟和蛋白质水平，导致轴突直径减小和外髓鞘层撕裂，从而破坏神经元功能。