N6-methyladenosine (m6A) is considered to be the most common and abundant epigenetics modification in messenger RNA (mRNA) and noncoding RNA. Abnormal modification of m6A is closely related to the occurrence, development, progression, and prognosis of cancer. m6A regulators have been identified as novel targets for anticancer drugs. Natural products, a rich source of traditional anticancer drugs, have been utilized for the development of m6A-targeting drugs. Here, we review the key role of m6A modification in cancer progression and explore the prospects and structural modification mechanisms of natural products as potential drugs targeting m6A modification for cancer treatment.

Teaser

The key role of m6A modification in cancer progression and prospects of natural products as potential drugs targeting m6A modification for cancer therapy are explored.

N6-甲基腺苷 (m6A) 被认为是信使 RNA (mRNA) 和非编码 RNA 中最常见、最丰富的表观遗传学修饰。m6A的异常修饰与癌症的发生、发展、进展及预后密切相关。m6A 调节因子已被确定为抗癌药物的新靶标。天然产物是传统抗癌药物的丰富来源，已被用于开发 m6A 靶向药物。在此，我们回顾了m6A修饰在癌症进展中的关键作用，并探讨了天然产物作为针对m6A修饰的潜在药物治疗癌症的前景和结构修饰机制。

预告片

探讨了 m6A 修饰在癌症进展中的关键作用，以及天然产物作为靶向 m6A 修饰的潜在药物用于癌症治疗的前景。