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TAMC-derived creatine sustains glioblastoma growth
Cell Metabolism ( IF 29.0 ) Pub Date : 2024-01-02 , DOI: 10.1016/j.cmet.2023.12.012
Huiwen Yan , Pengcheng Bu

Tumor-associated myeloid cells (TAMCs) are the predominant immune population in glioblastoma (GBM), but the definite role of TAMCs in GBM tumorigenicity remains uncertain. In this issue of Cell Metabolism, Rashidi et al. identify a specific population of TAMCs surrounding hypoxic regions of GBM. These TAMCs provide creatine to nearby tumor cells to promote GBM progression.



中文翻译:

TAMC 衍生的肌酸维持胶质母细胞瘤生长

肿瘤相关骨髓细胞(TAMC)是胶质母细胞瘤(GBM)中的主要免疫群体,但 TAMC 在 GBM 致瘤性中的明确作用仍不确定。在本期《细胞代谢》中,Rashidi 等人。识别 GBM 缺氧区域周围的特定 TAMC 群体。这些 TAMC 向附近的肿瘤细胞提供肌酸,以促进 GBM 进展。

更新日期:2024-01-02
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