Several clinical trials and experimental studies have recently shown that vitamin K (VK) supplementation benefits the human body. Specifically, VK participates in coagulation and is associated with cellular senescence and cancer. VK has a potential anticancer effect in various cancers, such as pancreatic and prostate cancers. Through anti-inflammatory and antioxidant effects, VK can prevent senescence and inhibit cancer metastasis. Therefore, cancer prognosis can be improved by preventing cellular senescence. In addition, VK can inhibit the proliferation, growth, and differentiation of cancer cells through various mechanisms, including induction of c-myc and c-fos genes, regulation of B-cell lymphoma-2 (Bcl-2) and p21 genes, and angiogenesis inhibition. This review aims to discuss the relationship among VK, cellular senescence, and cancer metastasis and thus may improve comprehension of the specific functions of VK in human health. The potential application of VK as an adjuvant therapy for cancer (or in combination with traditional chemotherapy drugs or other vitamins) has also been highlighted.

最近多项临床试验和实验研究表明，补充维生素 K (VK) 对人体有益。具体来说，VK 参与凝血并与细胞衰老和癌症相关。VK 对多种癌症具有潜在的抗癌作用，例如胰腺癌和前列腺癌。通过抗炎和抗氧化作用，VK可以预防衰老并抑制癌症转移。因此，可以通过预防细胞衰老来改善癌症预后。此外，VK 可通过多种机制抑制癌细胞的增殖、生长和分化，包括诱导c-myc和c-fos基因、调节 B 细胞淋巴瘤-2 ( Bcl-2)和p21基因，以及血管生成抑制。本综述旨在讨论 VK、细胞衰老和癌症转移之间的关系，从而可能提高对 VK 在人类健康中的特定功能的理解。VK 作为癌症辅助治疗（或与传统化疗药物或其他维生素联合使用）的潜在应用也得到了强调。