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Correction to Lyden P, Pryor KE, Coffey CS, et al. Final results of the RHAPSODY trial: a multi-center, phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A-APC, a recombinant variant of human activated protein C, in combination with tissue plasminogen activator, mechanical thrombectomy or both in moderate to severe acute ischemic stroke. Ann Neurol 2019;85:125–136.
Annals of Neurology ( IF 8.1 ) Pub Date : 2023-12-21 , DOI: 10.1002/ana.26841


In the copyediting for our paper, an extra line space was inserted in the last section of the Table giving the times to treatment for the two groups. This pushed the numbers for each category down one line. In addition, the timing until first treatment for the different groups (tPA, thrombectomy, tPA + thrombectomy) may not have been sufficiently clear without sample sizes and p values. The Table should have read:

Placebo, n = 44 3K3A-APC, n = 66 p
Time from stroke onset to first therapy (tPA, thrombectomy, or both), n = 110 2:07 (1:01) 2:13 (0:58) 0.57
Time to tPA initiation (tPA only), n = 59 1:59 (0:44) 2:16 (0:49) 0.19
Time to first skin puncture (thrombectomy only), n = 5 5:39 (0:21) 3:31 (1:37) 0.18
Time to tPA (tPA plus thrombectomy), n = 46 1:53 (0:35) 2:02 (1:00) 0.57
  • tPA = tissue plasminogen activator.



中文翻译:


对 Lyden P、Pryor KE、Coffey CS 等人的更正。 RHAPSODY 试验的最终结果:一项多中心、2 期试验,采用持续重新评估方法来确定 3K3A-APC(人活化蛋白 C 的重组变体)与组织纤溶酶原激活剂、机械血栓切除术或两者均适用于中度至重度急性缺血性中风。安·尼罗尔 2019;85:125–136。



在我们论文的文案编辑中,在表格的最后部分插入了额外的行距,给出了两组的治疗时间。这使得每个类别的数字下降了一行。此外,如果没有样本量和p值,不同组(tPA、血栓切除术、tPA + 血栓切除术)首次治疗的时间可能还不够明确。该表应为:

 安慰剂,n = 44  3K3A-APC,n = 66 p

从卒中发作到首次治疗(tPA、血栓切除术或两者)的时间,n = 110
2:07 (1:01) 2:13 (0:58) 0.57

tPA 启动时间(仅 tPA),n = 59
1:59 (0:44) 2:16 (0:49) 0.19

首次皮肤穿刺的时间(仅限血栓切除术),n = 5
5:39 (0:21) 3:31 (1:37) 0.18

tPA 时间(tPA 加血栓切除术),n = 46
1:53 (0:35) 2:02 (1:00) 0.57

  • tPA = 组织纤溶酶原激活剂。

更新日期:2023-12-21
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