We review recent advances in software platforms for model-based design (MBD) organized in five overarching themes — from (1) simulation to optimization, (2) commercial to open-source, (3) process-centric to multiscale, (4) mechanistic to data-driven, and (5) deterministic to uncertain — illustrated with several recent examples in membrane system design. We posit MBD provides (chemical) engineers with principled frameworks to tackle global grand challenges such as sustainable energy, clean water, and equitable access to healthcare by integrating knowledge across disciplines. As such, we predict MBD software, which has historically focused on engineered systems, will evolve to interact with models for natural and social systems more holistically. Finally, we emphasize the importance of open-source software development, especially by users who become contributors.

我们回顾了基于模型的设计（MBD）软件平台的最新进展，分为五个总体主题：（1）模拟到优化，（2）商业到开源，（3）以流程为中心到多尺度，（4）机械性到数据驱动，以及（5）确定性到不确定性——用膜系统设计中的几个最近的例子进行说明。我们认为 MBD 为（化学）工程师提供了原则性框架，通过整合跨学科知识来应对可持续能源、清洁水和公平获得医疗保健等全球重大挑战。因此，我们预测历来专注于工程系统的 MBD 软件将不断发展，以更全面地与自然和社会系统模型进行交互。最后，我们强调开源软件开发的重要性，尤其是成为贡献者的用户。