Despite the growing popular interest in sleep and diet, many gaps exist in our scientific understanding of the interaction between circadian rhythms and metabolism. In this Review, we explore a promising, bidirectional role for ghrelin in mediating this interaction. Ghrelin both influences and is influenced by central and peripheral circadian systems. Specifically, we focus on how ghrelin impacts outputs of circadian rhythm, including neuronal activity, circulating growth hormone levels, locomotor activity and eating behaviour. We also consider the effects of circadian rhythms on ghrelin expression and the consequences of disrupted circadian patterns, such as shift work and jet lag, on ghrelin secretion. Our Review is aimed at both the casual reader interested in gaining more insight into the scientific context surrounding the trending topics of sleep and metabolism, as well as experienced scientists in the fields of ghrelin and circadian biology seeking inspiration and a comprehensive overview of how these fields are related.

尽管人们对睡眠和饮食的兴趣日益浓厚，但我们对昼夜节律和新陈代谢之间相互作用的科学理解仍存在许多差距。在这篇综述中，我们探讨了生长素释放肽在介导这种相互作用中的一种有前景的双向作用。生长素释放肽既影响中枢和外周昼夜节律系统，又受中枢和外周昼夜节律系统的影响。具体来说，我们关注生长素释放肽如何影响昼夜节律的输出，包括神经元活动、循环生长激素水平、运动活动和饮食行为。我们还考虑了昼夜节律对生长素释放肽表达的影响，以及昼夜节律紊乱（例如轮班工作和时差反应）对生长素释放肽分泌的影响。我们的评论既针对那些有兴趣深入了解围绕睡眠和新陈代谢这一热门话题的科学背景的普通读者，也针对那些在生长素释放肽和昼夜节律生物学领域寻求灵感并全面概述这些领域如何运作的经验丰富的科学家。有关系。