Sonodynamic therapy (SDT) is the use of ultrasound (US) to excite sonosensitizers to produce reactive oxygen species (ROS) to induce tumor cell death, thereby achieving therapeutic purposes. Based on the strong tissue penetration ability of ultrasound, SDT can realize the treatment of deeper tumors, and it is targeted, can be specifically concentrated at the tumor site, and has little impact on surrounding normal tissues. It has broad clinical transformation prospects. Therefore, sonosensitizers are the key to SDT, and the exploration of sonosensitizers with excellent therapeutic performance has received great attention. We reviewed the development of ultrasound-inspired sound sensitizers for imaging and treatment. First, different types of sonosensitizers are introduced, the construction and performance of inorganic, organic and hybrid types of sonosensitizers are evaluated, followed by a review of different image-guided SDT, and finally the key problems and solutions in this field are discussed in detail.

声动力疗法（SDT）是利用超声波（US）激发声敏剂产生活性氧（ROS）诱导肿瘤细胞死亡，从而达到治疗目的。基于超声强大的组织穿透能力，SDT可以实现对较深肿瘤的治疗，而且针对性强，可以特异性集中在肿瘤部位，对周围正常组织影响很小。具有广阔的临床转化前景。因此，声敏剂是SDT的关键，具有优异治疗性能的声敏剂的探索受到高度关注。我们回顾了用于成像和治疗的超声声敏剂的发展。首先介绍不同类型的声敏剂，评估无机、有机和混合型声敏剂的结构和性能，然后回顾不同类型的图像引导SDT，最后详细讨论该领域的关键问题和解决方案。