High dietary fructose consumption is linked to multiple disease states, including cancer. Zhou and colleagues recently reported a novel mechanism where high dietary fructose levels increase acetate production by the gut microbiome increasing post-translational modification O-GlcNAcylation in liver cells, which contributes to disease progression in mouse models of hepatocellular carcinoma.

中文翻译：

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果糖通过微生物醋酸盐诱导的 O-GlcNAc 酰化促进肝癌

高膳食果糖摄入与多种疾病状态有关，包括癌症。 Zhou及其同事最近报道了一种新机制，即高膳食果糖水平会增加肠道微生物组产生的乙酸盐，从而增加肝细胞中翻译后修饰的O-GlcNAc糖基化，从而导致小鼠肝细胞癌模型的疾病进展。