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Bacterial antigens unleash tumor-targeting immunity
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2023-12-13 , DOI: 10.1016/j.chom.2023.11.001
Nina Boeck 1 , Zlatko Trajanoski 2 , Lorenzo Galluzzi 3
Affiliation  

The composition of the gut microbiome has been shown to influence disease outcome in patients with colorectal cancer (CRC). In a recent Nature Biotechnology article, Wang et al. demonstrate that killing CRC-associated bacteria with a liposomal antibiotic elicits CRC-targeting immune responses of therapeutic relevance as a consequence of epitope mimicry.



中文翻译:


细菌抗原释放肿瘤靶向免疫力



肠道微生物组的组成已被证明会影响结直肠癌 (CRC) 患者的疾病结果。在最近的《自然生物技术》文章中,Wang 等人。证明用脂质体抗生素杀死结直肠癌相关细菌,会由于表位拟态而引发具有治疗相关性的针对结直肠癌的免疫反应。

更新日期:2023-12-16
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