By exposing mice carrying a deletion of NADPH oxidase isoform 4, NOX4, specifically in pancreatic β cells (βNOX4−/−) to nutrient excess stimulated by a high-fat diet (HFD), this study aimed to elucidate the role of β-cell redox status in the development of meta-inflammation within the diabetic phenotype.

中文翻译：

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小鼠β细胞中的NADPH氧化酶4参与慢性营养超载引起的炎症

通过将NADPH氧化酶同种型4（NOX4）缺失的小鼠（特别是胰腺β细胞（βNOX4−/−））暴露于高脂肪饮食（HFD）刺激的营养过剩中，本研究旨在阐明β细胞的作用糖尿病表型内元炎症发展中的氧化还原状态。