LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8+ T cells for improving anti-PD-1 antibody therapy,OncoImmunology

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LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8+ T cells for improving anti-PD-1 antibody therapy
OncoImmunology ( IF 7.2 ) Pub Date : 2023-12-14 , DOI: 10.1080/2162402x.2023.2293511
Jiqi Shan _{1,

2} , Wei Jing _{1,

2} , Yu Ping _{1,

2} , Chunyi Shen _{1,

2} , Dong Han _{1,

2} , Fengsen Liu _{1,

2} , Yaqing Liu _{1,

2} , Congcong Li _{1,

2} , Yi Zhang _{1,

2,

3,

4,

5}

Affiliation

Anti-PD-1 antibody therapy has achieved success in tumor treatment; however, the duration of its clinical benefits are typically short. The functional state of intratumoral CD8+ T cells substantial...

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