BACKGROUND AND AIMS Hepatitis delta virus (HDV) leads to the most severe form of viral hepatitis; however, the prevalence of HDV is not well understood. Using real-world data from the All-Payer Claims Database (APCD), this study estimates the prevalence of HBV/HDV infection among the chronic hepatitis B (HBV) population and describes patient/clinical characteristics for adults with HBV/HDV infection in the United States (US). APPROACH AND RESULTS Adults (≥ 18 y) with ≥1 inpatient claim or ≥2 outpatient claims for HDV infection or HBV in the APCD from 1/1/2014 to 12/31/2020 were identified. HDV prevalence was calculated as the proportion of patients with HBV/HDV infection among total patients with HBV infection. Patient characteristics, socioeconomic status, advanced liver complications (e.g., cirrhosis, hepatocellular carcinoma), and comorbidities were assessed. A total of 6,719 -patients were diagnosed with HBV/HDV among 144,975 with HBV and 12-months of continuous data, for a prevalence of 4.6%. At diagnosis, 31.7% of patients with HBV/HDV had advanced liver complications, including compensated cirrhosis (16.3%) and decompensated cirrhosis (10.4%). Diabetes (50.5%), hypertension (49.8%), HIV infection (30.9%), were the top three comorbidities. CONCLUSION In a large database capturing approximately 80% of the US insured population, HBV/HDV infection prevalence was 4.6% among HBV-infected adults. HDV-infected patients had high rates of baseline liver complications and other comorbidities at time of diagnosis, suggesting potentially delayed diagnosis and/or treatment. Earlier identification of HBV/HDV infection among the HBV population may provide opportunities to improve linkage to care and treatment, thereby reducing the risk of liver-related morbidity and mortality.

中文翻译：

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美国乙型肝炎患者中丁型肝炎病毒感染的患病率和特征：对所有付款人索赔数据库的分析。

背景和目的 丁型肝炎病毒 (HDV) 会导致最严重的病毒性肝炎；然而，丁型肝炎病毒的流行情况尚不清楚。本研究利用来自全付款人索赔数据库 (APCD) 的真实数据，估计了慢性乙型肝炎 (HBV) 人群中 HBV/HDV 感染的患病率，并描述了慢性乙型肝炎 (HBV) 人群中 HBV/HDV 感染成人的患者/临床特征。美国（US）。方法和结果 确定了 2014 年 1 月 1 日至 2020 年 12 月 31 日期间在 APCD 中因 HDV 感染或 HBV 提出≥1 次住院索赔或 ≥ 2 次门诊索赔的成人（≥ 18 岁）。HDV患病率计算为HBV/HDV感染患者占HBV感染总患者的比例。评估患者特征、社会经济状况、晚期肝脏并发症（例如肝硬化、肝细胞癌）和合并症。在 144,975 名 HBV 患者和 12 个月的连续数据中，共有 6,719 名患者被诊断为 HBV/HDV，患病率为 4.6%。诊断时，31.7% 的 HBV/HDV 患者出现晚期肝脏并发症，包括代偿性肝硬化 (16.3%) 和失代偿性肝硬化 (10.4%)。合并症排名前三位的是糖尿病（50.5%）、高血压（49.8%）、HIV感染（30.9%）。结论 在涵盖约 80% 的美国参保人群的大型数据库中，HBV 感染成人中 HBV/HDV 感染率为 4.6%。HDV 感染患者在诊断时基线肝脏并发症和其他合并症的发生率很高，这表明可能会延迟诊断和/或治疗。在乙型肝炎人群中及早识别乙型肝炎病毒/丁型肝炎病毒感染可能会提供改善护理和治疗联系的机会，从而降低肝脏相关发病率和死亡率的风险。