OBJECTIVES A substantial proportion of esophageal adenocarcinoma (EAC) patients do not report GERD symptoms. This study aimed to compare the risk factor profiles and cancer stage at presentation of EAC patients with and without prior GERD. METHODS In this retrospective, cross-sectional study, EAC patients were divided into two cohorts: 1. EAC with prior GERD: patients who reported typical GERD symptoms (heartburn or regurgitation) ≥1 year before cancer diagnosis, and 2. EAC without prior GERD: patients who did not report prior GERD symptoms or reported symptoms within 1 year of their cancer diagnosis. Baseline demographics, risk factors, and cancer stage at presentation were compared between the two cohorts. Additionally, the distribution of patients based on numbers of BE/EAC-associated risk factors (1, 2, 3, 4, 5 or more) was examined in the symptomatic and asymptomatic cohorts. RESULTS Over 13 years, 388 EAC patients with prior GERD and 245 EAC patients without prior GERD were recruited. Both groups had similar baseline demographics and risk factors, but EAC patients with prior GERD were more likely to have a history of BE. Asymptomatic patients had more advanced disease. Patients with 3 or more BE/EAC related risk factors formed the largest proportion of patients in both the symptomatic and asymptomatic cohorts. CONCLUSIONS Esophageal adenocarcinoma patients with and without prior GERD symptoms are phenotypically similar, suggesting that BE screening efforts to prevent or detect early EAC should not be restricted to just those with GERD.

中文翻译：

---

既往有 GERD 症状的食管腺癌患者与无 GERD 的患者相似：一项横断面研究。

目标 相当一部分食管腺癌 (EAC) 患者没有报告 GERD 症状。本研究旨在比较患有和不患有胃食管反流病 (GERD) 的 EAC 患者就诊时的危险因素概况和癌症分期。方法 在这项回顾性横断面研究中，EAC 患者被分为两组：1. 既往患有 GERD 的 EAC：在癌症诊断前 ≥1 年报告典型 GERD 症状（胃灼热或反流）的患者；2. 既往没有 GERD 的 EAC ：未报告既往 GERD 症状或在癌症诊断后 1 年内报告症状的患者。对两个队列之间的基线人口统计数据、危险因素和就诊时的癌症分期进行了比较。此外，在有症状和无症状队列中检查了基于 BE/EAC 相关危险因素数量（1、2、3、4、5 或更多）的患者分布。结果 13 年来，招募了 388 名既往有 GERD 的 EAC 患者和 245 名既往没有 GERD 的 EAC 患者。两组患者的基线人口统计数据和危险因素相似，但患有 GERD 的 EAC 患者更有可能有 BE 病史。无症状患者患有更晚期的疾病。在有症状和无症状队列中，具有 3 个或更多 BE/EAC 相关危险因素的患者所占患者比例最大。结论 既往有或没有 GERD 症状的食管腺癌患者表型相似，表明预防或检测早期 EAC 的 BE 筛查工作不应仅限于患有 GERD 的患者。