Programmed cell death molecule 1 (PD-1) is a negative regulator of T cell activation; however, the mechanisms by which it acts are unclear. In this issue of Science Signaling , Paillon et al . show that PD-1 inhibits actin cytoskeletal rearrangements and associated effector responses in cytotoxic T cells.

中文翻译：

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Actin' off：PD-1 抑制免疫突触处的 F-肌动蛋白重排和脱颗粒

程序性细胞死亡分子 1 (PD-1) 是 T 细胞激活的负调节因子；然而，其作用机制尚不清楚。在本期的科学信号, 帕永等人。显示 PD-1 抑制细胞毒性 T 细胞中肌动蛋白细胞骨架重排和相关效应反应。