Platelet-rich fibrin (PRF) has been characterized as a regenerative biomaterial that is fully resorbed within a typical 2–3 week period. Very recently, however, a novel heating process was shown to extend the working properties of PRP/PRF from a standard 2–3 week period toward a duration of 4–6 months. Numerous clinicians have now utilized this extended-PRF (e-PRF) membrane as a substitute for collagen barrier membranes in various clinical applications, such as guided tissue/bone regeneration. This review article summarizes the scientific work to date on this novel technology, including its current and future applications in periodontology, implant dentistry, orthopedics and facial aesthetics. A systematic review was conducted investigating key terms including “Bio-Heat,” “albumin gel,” “albumin-PRF,” “Alb-PRF,” “extended-PRF,” “e-PRF,” “activated plasma albumin gel,” and “APAG” by searching databases such as MEDLINE, EMBASE and PubMed. Findings from preclinical studies demonstrate that following a simple 10-min heating process, the transformation of the liquid plasma albumin layer into a gel-like injectable albumin gel extends the resorption properties to at least 4 months according to ISO standard 10 993 (subcutaneous animal model). Several clinical studies have now demonstrated the use of e-PRF membranes as a replacement for collagen membranes in GTR/GBR procedures, closing lateral windows in sinus grafting procedures, for extraction site management, and as a stable biological membrane during recession coverage procedures. Furthermore, Alb-PRF may also be injected as a regenerative biological filler that lasts extended periods with advantages in joint injections, osteoarthritis and in the field of facial aesthetics. This article highlights the marked improvement in the stability and degradation properties of the novel Alb-PRF/e-PRF technology with its widespread future potential use as a potential replacement for collagen membranes with indications including extraction site management, GBR procedures, lateral sinus window closure, recession coverage among others, and further highlights its use as a biological regenerative filler for joint injections and facial aesthetics. It is hoped that this review will pioneer future opportunities and research development in the field, leading to further progression toward more natural and less costly biomaterials for use in medicine and dentistry.

中文翻译：

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延长富含血小板的纤维蛋白

富含血小板的纤维蛋白 (PRF) 被认为是一种再生生物材料，通常在 2-3 周内被完全吸收。然而，最近，一种新颖的加热工艺被证明可以将 PRP/PRF 的工作特性从标准的 2-3 周延长到 4-6 个月。现在，许多临床医生已在各种临床应用中使用这种扩展 PRF (e-PRF) 膜作为胶原屏障膜的替代品，例如引导组织/骨再生。这篇综述文章总结了迄今为止有关这项新技术的科学工作，包括其当前和未来在牙周病学、种植牙科、骨科和面部美学方面的应用。对包括“Bio-Heat”、“白蛋白凝胶”、“白蛋白-PRF”、“Alb-PRF”、“扩展-PRF”、“e-PRF”、“活化血浆白蛋白凝胶”等关键术语进行了系统回顾。 ”和“APAG”，通过搜索 MEDLINE、EMBASE 和 PubMed 等数据库。临床前研究结果表明，根据 ISO 标准 10 993（皮下动物模型），经过简单的 10 分钟加热过程，液体血浆白蛋白层转变为凝胶状可注射白蛋白凝胶，将吸收特性延长至至少 4 个月。 ）。多项临床研究现已证明，e-PRF 膜可在 GTR/GBR 手术中替代胶原膜、在鼻窦移植手术中关闭侧窗、用于拔牙部位管理，以及在衰退覆盖手术中作为稳定的生物膜。此外，Alb-PRF还可以作为再生生物填充剂进行注射，其持续时间较长，在关节注射、骨关节炎和面部美容领域具有优势。本文重点介绍了新型 Alb-PRF/e-PRF 技术在稳定性和降解特性方面的显着改善，以及其作为胶原膜潜在替代品的广泛未来潜在用途，适应症包括提取部位管理、GBR 手术、侧窦窗闭合、经济衰退报道等，并进一步强调其作为生物再生填充剂用于关节注射和面部美容的用途。希望本次审查能够开拓该领域的未来机遇和研究发展，从而进一步推动医学和牙科领域使用更天然、成本更低的生物材料。