BACKGROUND. Pemphigus, a rare autoimmune bullous disease mediated by antidesmoglein autoantibodies, can be controlled with systemic medication like rituximab and high-dose systemic corticosteroids combined with immunosuppressants. However, some patients continue to experience chronically recurrent blisters in a specific area and require long-term maintenance systemic therapy.

中文翻译：

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天疱疮慢性水疱中克隆性 CXCL13+CD4+ T 细胞和 Tregs 的微环境网络

背景。天疱疮是一种由抗桥粒芯糖蛋白自身抗体介导的罕见自身免疫性大疱性疾病，可以通过全身用药（如利妥昔单抗）和大剂量全身性皮质类固醇联合免疫抑制剂来控制。然而，一些患者在特定区域持续出现慢性复发性水疱，需要长期维持全身治疗。