Cross-sectional studies have indicated that individuals from sub-Saharan Africa (SSA) with chronic hepatitis B are a potential risk group for hepatocellular carcinoma (HCC). An international multicentre retrospective cohort study of individuals of SSA or Afro-Surinamese ethnicity or descent with chronic hepatitis B in the UK, Netherlands and Spain has examined the incidence of HCC in this population. Individuals of SSA or Afro-Surinamese ethnicity or descent had a 5-year and 10-year cumulative HCC risk of 1% and 2.4%, respectively. Importantly, the 10-year HCC risk was negligible for individuals without advanced fibrosis at baseline (0.7% versus 12.1% for individuals with advanced fibrosis) and for those with low baseline modified PAGE-B score (risk score for predicting HCC; 0.5% versus 2.9% in the intermediate and 15.9% in the high risk according to modified PAGE-B score).

横断面研究表明，来自撒哈拉以南非洲 (SSA) 的慢性乙型肝炎患者是肝细胞癌 (HCC) 的潜在危险人群。一项针对英国、荷兰和西班牙患有慢性乙型肝炎的 SSA 或非裔苏里南种族或血统个体的国际多中心回顾性队列研究调查了该人群中 HCC 的发病率。SSA 或非裔苏里南种族或血统的个体 5 年和 10 年累积 HCC 风险分别为 1% 和 2.4%。重要的是，对于基线时没有晚期纤维化的个体（晚期纤维化个体为 0.7% 对比 12.1%）和基线修正 PAGE-B 评分较低的个体（预测 HCC 的风险评分；0.5% 对比 12.1%），10 年 HCC 风险可以忽略不计。根据修改后的 PAGE-B 评分，中间风险为 2.9%，高风险为 15.9%）。