In this Correspondence, A. Sharma & C. Wolfrum report that DGAT1/2 pharmacological inhibition at post-absorptive phase in mice leads to increased fatty acid oxidation and reduced plasma fatty acid levels, which could open new therapeutic avenues to avoid GI complications observed in clinical trials.

中文翻译：

---

吸收后阶段的 DGAT 抑制通过增加 FA 氧化来减少血浆 FA。

在本通讯中，A. Sharma 和 C. Wolfrum 报告称，小鼠吸收后阶段的 DGAT1/2 药理抑制会导致脂肪酸氧化增加并降低血浆脂肪酸水平，这可能开辟新的治疗途径，以避免在小鼠体内观察到的胃肠道并发症。临床试验。