Myocardial infarction, stroke, and pulmonary embolism are all deadly conditions associated with excessive thrombus formation. Standard treatment for these conditions involves systemic delivery of thrombolytic agents to break up clots and restore blood flow; however, this treatment can impact the hemostatic balance in other parts of the vasculature, which can lead to excessive bleeding. To avoid this potential danger, targeted thrombolytic treatments that can successfully target thrombi and release an effective therapeutic load are necessary. Because activated platelets and fibrin make up a large proportion of clots, these two components provide ample opportunities for targeting. This review will highlight potential thrombus targeting mechanisms as well as recent advances in thrombolytic therapies which utilize blood-cells and clotting proteins to effectively target and lyse clots.

中文翻译：

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血细胞启发和凝块靶向溶栓疗法的最新进展。

心肌梗塞、中风和肺栓塞都是与过度血栓形成相关的致命疾病。这些病症的标准治疗包括全身输送溶栓剂以分解血栓并恢复血流；然而，这种治疗可能会影响脉管系统其他部分的止血平衡，从而导致过度出血。为了避免这种潜在的危险，有必要进行能够成功靶向血栓并释放有效治疗负荷的靶向溶栓治疗。由于活化的血小板和纤维蛋白构成了血栓的很大一部分，因此这两种成分提供了充足的靶向机会。本综述将重点介绍潜在的血栓靶向机制以及利用血细胞和凝血蛋白有效靶向和溶解凝块的溶栓疗法的最新进展。