Dietary interventions designed to examine the role of nutrition on childhood bone accrual have often focused on the role of individual micronutrients (eg, calcium, vitamin D, and zinc) and macronutrients (eg, protein). The osteogenic benefits of whole foods, such as eggs, are not well understood despite eggs being a source of high-quality nutrients and bioactive compounds known to positively influence bone. A significant positive cross-sectional association between whole egg consumption and tibia cortical bone mass has recently been shown in young children; however, randomized controlled trials (RCTs) have not been conducted. This study is a double-blind RCT in male and female children ages 9–13 years of different ancestries, designed to determine if consuming food products with whole eggs (equivalent to 8–10 eggs/wk) versus foods with milk or gelatin (placebo) over a 9-month period will improve measures of bone strength. Total body less head (TBLH) and lumbar spine bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed using dual-energy X-ray absorptiometry (DXA). DXA Z-scores were computed using published pediatric growth charts and were adjusted for height-for-age Z-score (HAZ). Mid-tibia cortical volumetric BMD, BMC, cortical area, total bone area, cortical thickness, and strength strain index were measured using peripheral quantitative computed tomography. Overall, there were no significant intervention effects for any bone outcomes. The increase in spine BMC_HAZ Z-score in the egg group versus the gelatin group approached significance (p = 0.07). Significant time effects in TBLH aBMD_HAZ Z-score occurred as all groups decreased over 9 months (p < 0.03). Most tibia cortical bone outcomes increased over time (all p < 0.02), but changes did not differ across intervention groups. Whole eggs provide important nutritional benefits for children, but the bone responses to consumption of 8–10 eggs/wk over a period of 9 months in children entering the early stages of puberty were small. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

中文翻译：

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食用全蛋对健康儿童骨质增生的影响：一项随机对照试验

旨在检查营养对儿童骨质增生的作用的膳食干预措施通常侧重于单个微量营养素（例如钙、维生素 D 和锌）和常量营养素（例如蛋白质）的作用。尽管鸡蛋是已知对骨骼产生积极影响的优质营养素和生物活性化合物的来源，但鸡蛋等天然食品的成骨益处尚不清楚。最近在幼儿中发现全蛋摄入量与胫骨皮质骨量之间存在显着的正相关关系。然而，尚未进行随机对照试验（RCT）。这项研究是一项针对 9-13 岁不同血统的男性和女性儿童的双盲随机对照试验，旨在确定是否食用含有全蛋的食品（相当于每周 8-10 个鸡蛋）与含有牛奶或明胶的食品（安慰剂） ）在 9 个月的时间内将改善骨强度的测量。使用双能 X 射线吸收测定法 (DXA) 评估全身无头颅 (TBLH) 和腰椎骨矿物质含量 (BMC) 以及面积骨矿物质密度 (aBMD)。DXA Z分数是使用已发表的儿科生长图表计算的，并根据年龄别身高Z分数 (HAZ) 进行调整。使用外周定量计算机断层扫描测量胫骨中部皮质体积 BMD、BMC、皮质面积、总骨面积、皮质厚度和强度应变指数。总体而言，对任何骨骼结果都没有显着的干预效果。与明胶组相比，鸡蛋组的脊柱 BMC _HAZ Z分数增加接近显着性（ p  = 0.07）。随着所有组在 9 个月内下降，TBLH aBMD _HAZ Z评分出现显着的时间效应 ( p  < 0.03)。大多数胫骨皮质骨结果随着时间的推移而增加（全部p  < 0.02），但干预组之间的变化没有差异。全蛋为儿童提供重要的营养益处，但对于进入青春期早期的儿童，在 9 个月的时间内每周摄入 8-10 个鸡蛋的骨骼反应很小。© 2023 作者。《Journal of Bone and Mineral Research》由 Wiley periodicals LLC 代表美国骨与矿物研究学会 (ASBMR) 出版。