Lipodystrophy syndromes are rare diseases characterized by low levels and an abnormal distribution of adipose tissue, caused by diverse genetic or acquired causes. These conditions commonly exhibit metabolic complications, including insulin resistance, diabetes, hypertriglyceridemia, nonalcoholic fatty liver disease, and adipose tissue dysfunction. Moreover, genetic lipodystrophic laminopathies exhibit a premature aging phenotype, emphasizing the importance of restoring adipose tissue distribution and function. In this opinion, we discuss the relevance of adipose tissue reestablishment as a potential approach to alleviate premature aging and age-related complications in genetic lipodystrophy syndromes.

脂肪营养不良综合征是一种罕见疾病，其特征是脂肪组织水平低且分布异常，由多种遗传或后天原因引起。这些病症通常表现出代谢并发症，包括胰岛素抵抗、糖尿病、高甘油三酯血症、非酒精性脂肪肝和脂肪组织功能障碍。此外，遗传性脂肪营养不良性核纤层蛋白病表现出过早衰老的表型，强调了恢复脂肪组织分布和功能的重要性。在这一观点中，我们讨论了脂肪组织重建作为减轻遗传性脂肪营养不良综合征过早衰老和年龄相关并发症的潜在方法的相关性。