Background and Hypothesis Corollary discharge mechanism suppresses the conscious auditory sensory perception of self-generated speech and attenuates electrophysiological markers such as the auditory N1 Event-Related Potential (ERP) during Electroencephalographic (EEG) recordings. This phenomenon contributes to self-identification and seems to be altered in people with schizophrenia. Therefore, its alteration could be related to the anomalous self-experiences (ASEs) frequently found in these patients. Study Design To analyze corollary discharge dysfunction as a possible substrate of ASEs, we recorded EEG ERP from 43 participants with schizophrenia and 43 healthy controls and scored ASEs with the ‘Inventory of Psychotic-Like Anomalous Self-Experiences’ (IPASE). Positive and negative symptoms were also scored with the ‘Positive and Negative Syndrome Scale for Schizophrenia’ (PANSS) and with the ‘Brief Negative Symptom Scale’ (BNSS) respectively. The N1 components were elicited by two task conditions: (1) concurrent listening to self-pronounced vowels (talk condition) and (2) subsequent non-concurrent listening to the same previously self-uttered vowels (listen condition). Study Results The amplitude of the N1 component elicited by the talk condition was lower compared to the listen condition in people with schizophrenia and healthy controls. However, the difference in N1 amplitude between both conditions was significantly higher in controls than in schizophrenia patients. The values of these differences in patients correlated significantly and negatively with the IPASE, PANSS, and BNSS scores. Conclusions These results corroborate previous data relating auditory N1 ERP amplitude with altered corollary discharge mechanisms in schizophrenia and support corollary discharge dysfunction as a possible underpinning of ASEs in this illness.

中文翻译：

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推论放电功能障碍是精神分裂症异常自我体验的可能根源

背景和假设 推论放电机制会抑制自生语音的有意识听觉感官知觉，并减弱脑电图 (EEG) 记录期间的听觉 N1 事件相关电位 (ERP) 等电生理标记。这种现象有助于自我认同，并且似乎在精神分裂症患者中发生了改变。因此，其改变可能与这些患者中常见的异常自我体验（ASE）有关。研究设计 为了分析作为 ASE 可能基础的推论放电功能障碍，我们记录了 43 名精神分裂症参与者和 43 名健康对照者的脑电图 ERP，并使用“精神病样异常自我体验清单”(IPASE) 对 ASE 进行评分。阳性和阴性症状也分别用“精神分裂症阳性和阴性症状量表”(PANSS) 和“短暂阴性症状量表”(BNSS) 进行评分。N1 组件是由两个任务条件引发的：（1）同时聆听自发音的元音（说话条件）和（2）随后非同时聆听先前自发音的相同元音（聆听条件）。研究结果 与精神分裂症患者和健康对照者的聆听条件相比，谈话条件引起的 N1 分量的幅度较低。然而，两种情况下 N1 振幅的差异在对照组中显着高于精神分裂症患者。患者中这些差异的值与 IPASE、PANSS 和 BNSS 评分显着呈负相关。结论 这些结果证实了先前关于精神分裂症中听觉 N1 ERP 振幅与改变的推论放电机制的数据，并支持推论放电功能障碍可能是这种疾病中 ASE 的基础。