Black men with prostate cancer have historically had worse outcomes than white men with prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential basis is that prostate cancers in Black men are biologically distinct from prostate cancers in white men. Evidence suggests that genetic and ancestral factors, molecular pathways involving androgen and non-androgen receptor signalling, inflammation, epigenetics, the tumour microenvironment and tumour metabolism are contributing factors to the racial disparities observed. Key genetic and molecular pathways linked to prostate cancer risk and aggressiveness have potential clinical relevance. Describing biological drivers of prostate cancer disparities could inform efforts to improve outcomes for Black men with prostate cancer.

从历史上看，患有前列腺癌的黑人男性的预后比患有前列腺癌的白人男性要差。造成这种结果差异的原因是多因素的，但一个潜在的基础是黑人男性的前列腺癌在生物学上与白人男性的前列腺癌不同。有证据表明，遗传和祖先因素、涉及雄激素和非雄激素受体信号传导的分子途径、炎症、表观遗传学、肿瘤微环境和肿瘤代谢是造成所观察到的种族差异的因素。与前列腺癌风险和侵袭性相关的关键遗传和分子途径具有潜在的临床意义。描述前列腺癌差异的生物学驱动因素可以为改善患有前列腺癌的黑人男性的治疗结果的努力提供信息。