Metabolic dysfunction-associated steatotic liver disease (MASLD) has a strong heritable component, and genome-wide association cohort studies are highlighting the major genetic determinants of this condition. A meta-analysis of these databases has now enabled expansion of the list of the inherited variants that modulate the risk of MASLD. The identification of new MASLD risk loci is improving comprehension of disease pathogenesis and individual risk stratification, and also enabling the identification of novel therapeutic targets and disease subtypes that might ultimately lead to a precision medicine approach.

中文翻译：

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MASLD 遗传结构知识不断发展的意义

代谢功能障碍相关的脂肪肝病 (MASLD) 具有很强的遗传成分，全基因组关联队列研究正在强调这种疾病的主要遗传决定因素。对这些数据库的荟萃分析现已扩展了调节 MASLD 风险的遗传变异列表。新的 MASLD 风险位点的识别正在提高对疾病发病机制和个体风险分层的理解，并且还能够识别新的治疗靶点和疾病亚型，最终可能导致精准医学方法。