Spatial heterogeneity of T cell repertoire across NSCLC tumors, tumor edges, adjacent and distant lung tissues,OncoImmunology

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Spatial heterogeneity of T cell repertoire across NSCLC tumors, tumor edges, adjacent and distant lung tissues
OncoImmunology ( IF 7.2 ) Pub Date : 2023-10-20 , DOI: 10.1080/2162402x.2023.2233399
Qikang Hu _{1,

2,

3} , Meredith L Frank ₄ , Yang Gao _{5,

6,

7,

8} , Liyan Ji ₉ , Muyun Peng _{1,

2,

3} , Chen Chen _{1,

2,

3} , Bin Wang _{1,

2,

3} , Yan Hu _{1,

2,

3} , Zeyu Wu _{1,

2,

3} , Jina Li _{1,

2,

3} , Lu Shu _{1,

2,

3} , Qiongzhi He ₉ , Yingqian Zhang ₉ , Xuefeng Xia ₉ , Jianjun Zhang _{4,

10,

11,

12} , Xin Yi ₉ , Alexandre Reuben ₄ , Fenglei Yu _{1,

2,

3}

Affiliation

Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, P. R. China.
Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer, The Second Xiangya Hospital of Central South University, Changsha, China.
Early-Stage Lung Cancer Center, The Second Xiangya Hospital of Central South University, Changsha, China.
Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, USA.
Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, P. R. China.
Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, China.
Hunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis & Treatment, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Changsha, China.
Geneplus-Beijing Institute, Beijing, China.
Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, USA.
Lung Cancer Genomics Program, University of Texas MD Anderson Cancer Center, Houston, USA.
Lung Cancer Interception Program, University of Texas MD Anderson Cancer Center, Houston, USA.

A better understanding of T cells in lung cancer and their distribution across tumor-adjacent lungs and peripheral blood is needed to improve efficacy and minimize toxicity from immunotherapy to lu...

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