Ferroptosis plays a key role in placental development and physiology, and abnormal ferroptosis has been implicated in trophoblast injury leading to preeclampsia (PE). We hypothesize that leukocytes isolated from PE exhibit increased ferroptosis and that extracellular vesicles contain long non-coding (lnc) RNA/mRNAs that modulate oxidative stress and iron toxicity in vascular endothelial cells.

中文翻译：

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先兆子痫女性白细胞铁死亡增加涉及长非编码牛磺酸上调基因 1 (TUG1)

铁死亡在胎盘发育和生理学中起着关键作用，异常铁死亡与滋养层损伤导致先兆子痫（PE）有关。我们假设从 PE 中分离的白细胞表现出铁死亡增加，并且细胞外囊泡含有长非编码 (lnc) RNA/mRNA，可调节血管内皮细胞的氧化应激和铁毒性。