Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: The PULSES trial,Journal of Internal Medicine

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Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: The PULSES trial
Journal of Internal Medicine ( IF 11.1 ) Pub Date : 2023-10-19 , DOI: 10.1111/joim.13721
Georgina Russell _{1,

2,

3} , Konstantinos Kalafatakis _{1,

4,

5,

6} , Claire Durant ₇ , Nicola Marchant _{1,

2} , Jamini Thakrar _{1,

5} , Russell Thirard ₈ , Jade King _{2,

3} , Jane Bowles _{1,

2} , Thomas Upton ₁ , Ngoc Jade Thai _{5,

9} , Jonathan C. W. Brooks ₁₀ , Aileen Wilson ₅ , Kirsty Phillips ₂ , Stuart Ferguson ₁₁ , Meryem Grabski ₁₂ , Chris A. Rogers ₈ , Theodoros Lampros ₄ , Sue Wilson ₇ , Catherine Harmer ₁₃ , Marcus Munafo ₁₄ , Stafford L. Lightman _{1,

2}

Affiliation

Laboratories of Integrative Neuroscience and Endocrinology Bristol Medical School University of Bristol Bristol UK
University Hospital Bristol and Weston NHS Foundation Trust Bristol UK
North Bristol NHS Trust Bristol UK
Department of Informatics and Telecommunications, Human‐Computer Interaction Laboratory University of Ioannina Arta Greece
Clinical Research and Imaging Centre University of Bristol Bristol UK
Faculty of Medicine and Dentistry (Malta Campus) Queen Mary University of London Victoria Malta
Department of Brain Sciences Faculty of Medicine Imperial College London London UK
Bristol Trials Centre Bristol Medical School University of Bristol Bristol UK
Neurosciences and Mental Health Liverpool Health Partners Liverpool UK
School of Psychology University of East Anglia Norwich UK
School of Medicine University of Tasmania Hobart Tasmania Australia
Division of Psychology and Language Sciences UCL London UK
Department of Psychiatry Oxford University and Oxford Health NHS Foundation Trust Oxford UK
MRC Integrative Epidemiology Unit School of Psychological Science University of Bristol Bristol UK

Primary adrenal insufficiency (PAI) mortality and morbidity remain unacceptably high, possibly arising as glucocorticoid replacement does not replicate natural physiology. A pulsatile subcutaneous pump can closely replicate cortisol's circadian and ultradian rhythm.

中文翻译：

Ultradian 氢化可的松替代品改变肾上腺功能不全患者的神经元处理、情绪模糊、情感和疲劳：PULSES 试验

原发性肾上腺皮质功能不全 (PAI) 的死亡率和发病率仍然高得令人无法接受，这可能是由于糖皮质激素替代疗法无法复制自然生理学所致。脉动皮下泵可以精确地复制皮质醇的昼夜节律和亚昼夜节律。

更新日期：2023-10-19

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