Cell death can be executed through distinct subroutines. PANoptosis is a unique inflammatory cell death modality involving the interactions between pyroptosis, apoptosis, and necroptosis, which can be mediated by multifaceted PANoptosome complexes assembled via integrating components from other cell death modalities. There is growing interest in the process and function of PANoptosis. Accumulating evidence suggests that PANoptosis occurs under diverse stimuli, for example, viral or bacterial infection, cytokine storm, and cancer. Given the impact of PANoptosis across the disease spectrum, this review briefly describes the relationships between pyroptosis, apoptosis, and necroptosis, highlights the key molecules in PANoptosome formation and PANoptosis activation, and outlines the multifaceted roles of PANoptosis in diseases together with a potential for therapeutic targeting. We also discuss important concepts and pressing issues for future PANoptosis research. Improved understanding of PANoptosis and its mechanisms is crucial for identifying novel therapeutic targets and strategies.

中文翻译：

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全下视：机制、生物学和在疾病中的作用

细胞死亡可以通过不同的子程序来执行。PANoptosis 是一种独特的炎症细胞死亡方式，涉及细胞焦亡、细胞凋亡和坏死性凋亡之间的相互作用，可以通过整合其他细胞死亡方式的成分组装而成的多面 PANoptosome 复合物介导。人们对 PANoptosis 的过程和功能越来越感兴趣。越来越多的证据表明，全凋亡在多种刺激下发生，例如病毒或细菌感染、细胞因子风暴和癌症。鉴于 PANoptosis 在整个疾病谱中的影响，这篇综述简要描述了焦亡、细胞凋亡和坏死性凋亡之间的关系，强调了 PANoptosis 形成和 PANoptosis 激活中的关键分子，并概述了 PANoptosis 在疾病中的多方面作用以及治疗潜力。瞄准。我们还讨论了未来 PANoptosis 研究的重要概念和紧迫问题。加深对全视神经病变及其机制的了解对于确定新的治疗靶点和策略至关重要。