Ischemic cardiac injury causes irreversible muscle loss and scarring, but recent years have seen dramatic advances in cardiac reprogramming, the field focused on regenerating cardiac muscle. With SARS-CoV2 increasing the age-adjusted cardiovascular disease mortality rate, it is worth evaluating the state of this field. Here, we summarize novel innovations in reprogramming strategies, insights into their mechanisms, and technologies for factor delivery. We also propose a broad model of reprogramming to suggest directions for future research. Poet Emily Dickinson wrote, “If I can stop one heart from breaking, I shall not live in vain.” Today, researchers studying cardiac reprogramming view this line as a call to action to translate this revolutionary approach into life-saving treatments for patients with cardiovascular diseases.

缺血性心脏损伤会导致不可逆的肌肉损失和疤痕，但近年来，心脏重编程领域取得了巨大进展，该领域的重点是心肌再生。随着 SARS-CoV2 增加年龄调整的心血管疾病死亡率，该领域的现状值得评估。在这里，我们总结了重编程策略的新颖创新、对其机制的见解以及因子传递技术。我们还提出了一个广泛的重编程模型，为未来的研究方向提出建议。诗人艾米莉·狄金森写道：“如果我能阻止一颗心破碎，我就不会白活。” 如今，研究心脏重编程的研究人员将这条路线视为行动号召，将这一革命性方法转化为心血管疾病患者的挽救生命的治疗方法。