Per- and polyfluoroalkyl substances (PFAS) are water-soluble chemicals of concern due to their persistence, ubiquity, and toxicity. We explored correlations between drinking water and blood PFAS levels in a subset of the mother-child Barcelona Life Study Cohort (BiSC), Barcelona, Spain (2021). For 105 study participants, we analyzed 35 PFAS in tap water (unfiltered and filtered) and 23 PFAS in 98 paired plasma samples during the 3rd trimester, using LC-MS/MS. Water consumption habits were ascertained at the third trimester through questionnaires. The majority of participants consumed bottled water (56.2%), 5/35 PFAS were detected in unfiltered tap water, 4/35 PFAS in activated carbon filtered tap water samples, and 14/23 PFAS in plasma samples. Our results showed that PFHpA at the observed concentrations in drinking water was significantly correlated with paired plasma levels (R = 0.2; p = 0.04).

中文翻译：

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怀孕期间配对自来水和血液样本中全氟烷基物质和多氟烷基物质 (PFAS) 的浓度

全氟烷基物质和多氟烷基物质 (PFAS) 因其持久性、普遍性和毒性而成为令人关注的水溶性化学品。我们在西班牙巴塞罗那（2021 年）母子巴塞罗那生命研究队列 (BiSC) 的子集中探讨了饮用水与血液 PFAS 水平之间的相关性。对于 105 名研究参与者，我们使用 LC-MS/MS 分析了妊娠第三个月期间自来水（未过滤和过滤）中的 35 种 PFAS 以及 98 份配对血浆样本中的 23 种 PFAS。通过问卷调查确定妊娠晚期的饮水习惯。大多数参与者饮用瓶装水（56.2%），在未过滤的自来水中检测到 5/35 PFAS，在活性炭过滤的自来水样本中检测到 4/35 PFAS，在血浆样本中检测到 14/23 PFAS。