This systematic review (SR) aimed to evaluate the antimicrobial potential of different types of platelet-rich fibrin (PRF) often used in regenerative treatments. An electronic search was performed in four databases and in Gray literature for articles published until January, 2023. The eligibility criteria comprised in vitro studies that evaluated the antimicrobial effect of different types of PRF. For the analysis of the risk of bias within studies, the modified OHAT (Office of Health Assessment and Translation) tool was used. For the evaluation of the results, a qualitative critical analysis was carried out in the synthesis of the results of the primary studies. Sixteen studies published between 2013 and 2021 were included in this SR. The antimicrobial effects of PRF variations (PRF, injectable PRF [I-PRF], PRF with silver nanoparticles [agNP-PRF], and horizontal PRF [H-PRF]), were analyzed against 16 types of bacteria from the oral, periodontal, and endodontic environments. All types of PRF showed significant antimicrobial action, with the antibacterial efficacy being more expressive than the fungal one. The I-PRF, H-PRF, and agNP-PRF subtypes improve antimicrobial activity. According to the OHAT analysis, no study was classified as having a high risk of bias. Evidence suggests that PRF variations have significant antimicrobial activity, with bacterial action being greater than fungal. Evolutions such as I-PRF, H-PRF, and agNP-PRF improve antimicrobial activity. Future studies analyzing the clinical effect of these platelets are fundamental.

中文翻译：

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富含血小板的纤维蛋白的抗菌作用：体外循证研究的系统评价

本系统评价 (SR) 旨在评估常用于再生治疗的不同类型的富血小板纤维蛋白 (PRF) 的抗菌潜力。在四个数据库和灰色文献中对截至 2023 年 1 月发表的文章进行了电子检索。资格标准包括评估不同类型 PRF 抗菌效果的体外研究。为了分析研究中的偏倚风险，使用了修改后的 OHAT（健康评估和翻译办公室）工具。为了评估结果，在综合初步研究结果时进行了定性批判性分析。本 SR 中包含 2013 年至 2021 年期间发表的 16 项研究。针对来自口腔、牙周、口腔和口腔的 16 种细菌，分析了不同 PRF（PRF、注射式 PRF [I-PRF]、含银纳米粒子的 PRF [agNP-PRF] 和水平 PRF [H-PRF]）的抗菌效果。和牙髓环境。所有类型的PRF均表现出显着的抗菌作用，其抗菌功效比真菌功效更强。I-PRF、H-PRF 和 agNP-PRF 亚型可提高抗菌活性。根据 OHAT 分析，没有研究被归类为具有高偏倚风险。有证据表明，PRF 变异具有显着的抗菌活性，其中细菌作用大于真菌。I-PRF、H-PRF 和 agNP-PRF 等进化可提高抗菌活性。未来研究分析这些血小板的临床效果至关重要。