Abstract

Magnetic Drug Targeting (MDT) is of particular interest to researchers because of its good loading efficiency, targeting accuracy, and versatile use in vivo. Cardiovascular Disease (CVD) is a global chronic disease with a high mortality rate, and the development of more precise and effective treatments is imminent. A growing number of studies have begun to explore the feasibility of MDT in CVD, but an up-to-date systematic summary is still lacking. This review discusses the current research status of MDT from guiding magnetic fields, magnetic nanocarriers, delivery channels, drug release control, and safety assessment. The current application status of MDT in CVD is also critically introduced. On this basis, new insights into the existing problems and future optimization directions of MDT are further highlighted.

摘要

磁性药物靶向（MDT）因其良好的装载效率、靶向准确性和体内的多功能性而受到研究人员的特别关注。心血管疾病（CVD）是一种死亡率较高的全球性慢性疾病，开发更精准有效的治疗方法迫在眉睫。越来越多的研究开始探索MDT治疗CVD的可行性，但仍缺乏最新的系统总结。本文从引导磁场、磁性纳米载体、递送通道、药物释放控制和安全性评估等方面讨论了MDT的研究现状。还重点介绍了MDT在CVD中的应用现状。在此基础上，进一步凸显了对MDT存在问题和未来优化方向的新见解。