Abstract

Intestinal inflammation modifies host physiology to promote the occurrence of colorectal cancer (CRC), as seen in colitis-associated CRC. Gut microbiota is crucial in cancer progression, primarily by inducing intestinal chronic inflammatory microenvironment, leading to DNA damage, chromosomal mutation, and alterations in specific metabolite production. Therefore, there is an increasing interest in microbiota-based prevention and treatment strategies, such as probiotics, prebiotics, microbiota-derived metabolites, and fecal microbiota transplantation. This review aims to provide valuable insights into the potential correlations between gut microbiota and colitis-associated CRC, as well as the promising microbiota-based strategies for colitis-associated CRC.

摘要

肠道炎症改变宿主生理机能，促进结直肠癌 (CRC) 的发生，如结肠炎相关的 CRC 所示。肠道微生物群在癌症进展中至关重要，主要是通过诱导肠道慢性炎症微环境，导致 DNA 损伤、染色体突变和特定代谢物产生的改变。因此，人们对基于微生物群的预防和治疗策略越来越感兴趣，例如益生菌、益生元、微生物群衍生的代谢物和粪便微生物群移植。本综述旨在为肠道微生物群与结肠炎相关 CRC 之间的潜在相关性以及基于微生物群的结肠炎相关 CRC 治疗策略提供有价值的见解。