Abstract

Kartogenin, a small and heterocyclic molecule, has emerged as a promising therapeutic agent for incorporation into biomaterials, owing to its unique physicochemical and biological properties. It holds potential for the regeneration of cartilage-related tissues in various common conditions and injuries. Achieving sustained release of kartogenin through appropriate formulation and efficient delivery systems is crucial for modulating cell behavior and tissue function. This review provides an overview of cutting-edge kartogenin-functionalized biomaterials, with a primarily focus on their design, structure, functions, and applications in regenerative medicine. Initially, we discuss the physicochemical properties and biological functions of kartogenin, summarizing the underlying molecular mechanisms. Subsequently, we delve into recent advancements in nanoscale and macroscopic materials for the carriage and delivery of kartogenin. Lastly, we address the opportunities and challenges presented by current biomaterial developments and explore the prospects for their application in tissue regeneration. We aim to enhance the generation of insightful ideas for the development of kartogenin delivery materials in the field of biomedical therapeutics and regenerative medicine by providing a comprehensive understanding of common preparation methods.

摘要

Kartogenin 是一种杂环小分子，由于其独特的理化和生物学特性，已成为一种有前途的生物材料治疗剂。它具有在各种常见情况和损伤中再生软骨相关组织的潜力。通过适当的配方和有效的递送系统实现卡托根元的持续释放对于调节细胞行为和组织功能至关重要。本综述概述了尖端的卡托根元功能化生物材料，主要关注其设计、结构、功能以及在再生医学中的应用。首先，我们讨论了kartogenin的理化性质和生物学功能，总结了潜在的分子机制。随后，我们深入研究了用于运输和递送卡托根元的纳米级和宏观材料的最新进展。最后，我们讨论了当前生物材料发展带来的机遇和挑战，并探讨了其在组织再生中的应用前景。我们的目标是通过提供对常见制备方法的全面了解，促进在生物医学治疗和再生医学领域开发卡托皂苷元递送材料的富有洞察力的想法的产生。