A unique cytotoxic CD4+ T cell-signature defines critical COVID-19,Clinical & Translational Immunology

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A unique cytotoxic CD4+ T cell-signature defines critical COVID-19
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2023-08-28 , DOI: 10.1002/cti2.1463
Sarah Baird _{1,

2} , Caroline L Ashley _{1,

2} , Felix Marsh-Wakefield _{2,

3,

4} , Sibel Alca _{1,

2} , Thomas M Ashhurst _{2,

5} , Angela L Ferguson _{2,

3} , Hannah Lukeman _{1,

2} , Claudio Counoupas _{1,

2,

6} , Jeffrey J Post _{7,

8} , Pamela Konecny _{7,

9} , Adam Bartlett _{10,

11,

12} , Marianne Martinello ₁₀ , Rowena A Bull _{10,

11} , Andrew Lloyd _{10,

11} , Alice Grey ₁₃ , Owen Hutchings ₁₃ , Umaimainthan Palendira _{2,

3} , Warwick J Britton _{6,

14} , Megan Steain _{1,

2} , James A Triccas _{1,

2}

Affiliation

Sydney Infectious Diseases Institute, Faculty of Medicine and Health The University of Sydney NSW Camperdown Australia.
School of Medical Sciences and Charles Perkins Centre The University of Sydney Camperdown NSW Australia.
Liver Injury and Cancer Program Centenary Institute Camperdown NSW Australia.
Human Cancer and Viral Immunology Laboratory The University of Sydney Camperdown NSW Australia.
Sydney Cytometry Core Research Facility Charles Perkins Centre, Centenary Institute and The University of Sydney Camperdown NSW Australia.
Tuberculosis Research Program Centenary Institute Sydney NSW Australia.
Prince of Wales Clinical School UNSW Sydney NSW Australia.
School of Clinical Medicine, Medicine & Health UNSW Sydney NSW Australia.
St George Hospital Sydney NSW Australia.
The Kirby Institute, UNSW Sydney NSW Australia.
School of Biomedical Sciences, Medicine & Health UNSW Sydney NSW Australia.
Sydney Children's Hospital Sydney NSW Australia.
RPA Virtual Hospital, Sydney Local Health District Sydney NSW Australia.
Department of Clinical Immunology Royal Prince Alfred Hospital Camperdown NSW Australia.

SARS-CoV-2 infection causes a spectrum of clinical disease presentation, ranging from asymptomatic to fatal. While neutralising antibody (NAb) responses correlate with protection against symptomatic and severe infection, the contribution of the T-cell response to disease resolution or progression is still unclear. As newly emerging variants of concern have the capacity to partially escape NAb responses, defining the contribution of individual T-cell subsets to disease outcome is imperative to inform the development of next-generation COVID-19 vaccines.

中文翻译：

独特的细胞毒性 CD4+ T 细胞特征定义了关键的 COVID-19

SARS-CoV-2 感染会导致一系列临床疾病表现，从无症状到致命。虽然中和抗体 (NAb) 反应与针对症状和严重感染的保护相关，但 T 细胞反应对疾病消退或进展的贡献仍不清楚。由于新出现的令人关注的变体有能力部分逃避 NAb 反应，因此确定个体 T 细胞亚群对疾病结果的贡献对于下一代 COVID-19 疫苗的开发至关重要。

更新日期：2023-08-29

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