Bacterial infections pose a severe threat to human health due to the exacerbation of antibiotic resistance and intracellular bacterial infections. Research suggests that oligo(p-phenylene vinylene) (OPV), commonly employed in the manufacture of organic solar batteries, can help address this issue. This study demonstrates the ability of OPV to target and sterilize intracellular Porphyromonas gingivalis and methicillin-resistant Staphylococcus aureus (MRSA) photodynamically. Most notably, OPV specifically targets bacteria without affecting healthy cells under dark conditions. Its chemical composition includes a conjugated backbone and ionic imidazole side chains, which allow OPV to bind to cell membranes. Furthermore, dental blue light curing lamps may excite OPV. Compared with antibiotics and traditional photosensitizers, OPV proves to be a potentially superior solution to eradicate intracellular microbial infections, both in fundamental research and clinical applications.

由于抗生素耐药性和细胞内细菌感染的加剧，细菌感染对人类健康构成严重威胁。研究表明，通常用于制造有机太阳能电池的低聚（对亚苯基亚乙烯基）（OPV）可以帮助解决这个问题。这项研究证明了 OPV 能够靶向并杀死细胞内牙龈卟啉单胞菌和耐甲氧西林金黄色葡萄球菌( MRSA)）光动力。最值得注意的是，OPV 专门针对细菌，在黑暗条件下不会影响健康细胞。其化学成分包括共轭主链和离子咪唑侧链，使 OPV 能够与细胞膜结合。此外，牙科蓝光固化灯可能会激发 OPV。与抗生素和传统光敏剂相比，无论是在基础研究还是临床应用中，OPV 都被证明是根除细胞内微生物感染的潜在优越解决方案。