In recent years, a growing understanding of the underlying mechanisms of autoinflammatory and autoimmune disease has enabled significant advances in biomaterial therapeutics for their treatment and prevention. Drug-free or immune-active polymeric materials are of particular interest due to their chemical tunability, multifaceted mechanisms of action, and potential to offer alternatives to conventional treatments. While in many cases the relationships between polymer physicochemical properties and the immune processes they influence are context-dependent and require further clarity, several concepts are emerging that can be applied in the design of anti-inflammatory materials. This review highlights recent work that investigates these relationships, as well as work that applies them to immunomodulatory biomaterials for the treatment or prevention of autoimmune and autoinflammatory diseases.

近年来，人们对自身炎症和自身免疫性疾病的潜在机制的了解不断加深，使得生物材料疗法在治疗和预防方面取得了重大进展。无药物或免疫活性聚合物材料因其化学可调性、多方面的作用机制以及提供传统治疗替代方案的潜力而受到特别关注。虽然在许多情况下，聚合物物理化学性质和它们影响的免疫过程之间的关系是依赖于环境的并且需要进一步明确，但正在出现一些可应用于抗炎材料设计的概念。这篇评论重点介绍了最近研究这些关系的工作，