Peroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as H₂O₂ detoxifiers, and more recently as H₂O₂ sensors, intermediates in redox-signaling pathways, metabolism modulators, and chaperones.

The multifaceted nature of Prx is not only dependent on their peroxidase activity but also strongly associated with specific protein–protein interactions that are being identified, and where the Prx oligomerization dynamics plays a role. Their oxidation by a peroxide substrate forms a sulfenic acid that opens a route to channel the redox signal to diverse protein targets.

Recent research underscores the importance of different Prx isoforms in the cellular processes behind disease development with potential therapeutic applications.

过氧化还原蛋白 (Prx) 是一种硫醇依赖性过氧化物酶，最初被鉴定为 H ₂ O ₂解毒剂，最近被鉴定为 H ₂ O ₂传感器、氧化还原信号通路的中间体、代谢调节剂和分子伴侣。

Prx 的多方面性质不仅取决于其过氧化物酶活性，而且与正在鉴定的特定蛋白质-蛋白质相互作用密切相关，而 Prx 寡聚动力学在其中发挥作用。它们被过氧化物底物氧化形成次磺酸，开辟了一条将氧化还原信号引导至不同蛋白质靶标的途径。

最近的研究强调了不同 Prx 亚型在疾病发展背后的细胞过程中的重要性以及潜在的治疗应用。