INTRODUCTION Helicobacter pylori colonizes the human stomach. Infection causes chronic gastritis and increases the risk of gastroduodenal ulcer and gastric cancer. Its chronic colonization in the stomach triggers aberrant epithelial and inflammatory signals that are also associated with systemic alterations. METHODS Using a PheWAS analysis in more than 8,000 participants in the community-based UK Biobank, we explored the association of H. pylori positivity with gastric and extragastric disease and mortality in a European country. RESULTS Along with well-established gastric diseases, we dominantly found overrepresented cardiovascular, respiratory, and metabolic disorders. Using multivariate analysis, the overall mortality of H. pylori -positive participants was not altered, while the respiratory and Coronovirus 2019-associated mortality increased. Lipidomic analysis for H. pylori -positive participants revealed a dyslipidemic profile with reduced high-density lipoprotein cholesterol and omega-3 fatty acids, which may represent a causative link between infection, systemic inflammation, and disease. DISCUSSION Our study of H. pylori positivity demonstrates that it plays an organ- and disease entity-specific role in the development of human disease and highlights the importance of further research into the systemic effects of H. pylori infection.

中文翻译：

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幽门螺杆菌阳性与疾病和死亡风险的关联。

简介 幽门螺杆菌定植于人类胃中。感染会导致慢性胃炎，并增加胃十二指肠溃疡和胃癌的风险。它在胃中的慢性定植会引发异常的上皮和炎症信号，这些信号也与全身改变有关。方法 通过对英国生物银行社区的 8,000 多名参与者进行 PheWAS 分析，我们探讨了欧洲国家幽门螺杆菌阳性与胃部和胃外疾病及死亡率的关联。结果 除了明确的胃部疾病外，我们还发现心血管、呼吸和代谢疾病的比例过高。通过多变量分析，幽门螺杆菌阳性参与者的总体死亡率没有改变，而呼吸道疾病和 2019 年冠状病毒相关的死亡率却有所增加。对幽门螺杆菌阳性参与者的脂质组学分析显示，其血脂异常特征包括高密度脂蛋白胆固醇和 omega-3 脂肪酸降低，这可能代表感染、全身炎症和疾病之间的因果关系。讨论 我们对幽门螺杆菌阳性的研究表明，它在人类疾病的发展中发挥着器官和疾病实体特异性的作用，并强调了进一步研究幽门螺杆菌感染的全身影响的重要性。